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KMID : 0882420100790030277
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Korean Journal of Medicine
2010 Volume.79 No. 3 p.277 ~ p.284
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LDL cholesterols levels after statin treatment: A comparison of measured vs. estimated values
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Kim Hyeon-Jin
Suk Ji-Hye
Kang Ji-Hyun
Kwon Hyuk-Yong
Hwang Chi-Sung
Kim Myoung-Joon
Kim Mi-Kyung
Kim Tae-Ik
Kim In-Ju
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Abstract
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Background/Aims: Lowering low-density lipoprotein cholesterol (LDL-C) is the primary target for the prevention of cardiovascular disease. Previous studies have shown that estimated LDL-C levels calculated using Friedewald’s formula (FLDL-C) are closely correlated with directly measured LDL-C levels (DLDL-C). However, because statins not only reduce LDL-C, but also alter the levels of parameters used to calculate FLDL-C (i.e., total cholesterol, triglycerides, and high-density lipoprotein cholesterol), whether calculated LDL-C levels remain a reliable estimate of actual levels after statin treatment is unclear.
Methods: Subjects included 985 patients at high risk of cardiovascular disease who had taken statins for more than 6 months. FLDL-C data were compared to DLDL-C data.
Results: A strong correlation was observed between DLDL-C and FLDL-C data (R2=0.879). However, the absolute values for FLDL-C and DLDL-C differed significantly according to a paired t-test, and 42.3% of patients showed a difference of greater than 10% between these two values. Among patients with diabetes, the percentage of patients deemed to have achieved target LDL-C levels differed significantly according to the method of LDL-C determination (p=0.007).
Conclusions: FLDL-C and DLDL-C data remained well correlated after statin treatment, although the absolute values differed significantly according to the LDL-C determination method. Furthermore, the percentage of subjects deemed to achieve target LDL-C levels differed significantly according to the method of determination among patients with diabetes.
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KEYWORD
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LDL cholesterol, Diabetes mellitus, Statins
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